Fred Destin

My two cents on how VCs should make decisions: 🚀 Can this be one of the 2–3 companies that returns 1X+ the fund — and can we get conviction on that early enough to build ownership? Everything el...

Boards suck (Founder NPS: -36). Here are a few questions I ask myself to make them better. And to remind myself - a good board meeting is never, ever about me 🕊️ . 😤 How is everyone feeling? Anx...

Q: What is the absolute worst software around in an industry where we can have some form of environmental impact? A: Road transport. This is the Q&A that Adriaan Coppens, Joeri De Turck and Sande...

I am open sourcing how we manage reserves in the most unvarnished and transparent way possible. This should give founders an insight as to how the sausage gets made, and may be helpful to emerging ...

Every one of our investments shapes the world. Every single one. I applaud Judith with both hands, for challenging the stories we tell ourselves, for (humbly) seeking greater moral ambition, for ...

"Evidence from the edge" suggests to me that 2026 will start to show AI delivering efficiency & efficacy in Enterprise. If 2025 was the year of runaway usage of generic chatbots, premature scalin...

Today for something completely different ❤️ . I'd like to contribute something here which is "what have I learned from Buddha which helps me lead a good life" i.e. staying away from complex consid...

"When complexity exceeds my ability to navigate it, I start writing about not knowing, and see where it leads." I'm borrowing this from Alexander Beiner as the perfect "embodiment" of where I stan...

What does wisdom look like? And why does it feel so much like not knowing? "There are two kinds of people. Those who do not understand how complex the world is, and those who know that they do no...

Can you trust AI? It's an important question when you're automating critical workflows. We need to design for trust. And to crack the code on trust requires opening the AI black box. One comp...

Lost a founder and a friend this week. I am quietly mourning Joshua Abram, co-founder and CEO of Conceivable Life Sciences. Alan Murray and Joshua Abram, a formidable pair of inventors and builde...